Non-Motor Off Symptoms in Parkinson's Disease

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Non-Motor Off Symptoms in Parkinson's Disease

The aim of this study is to elucidate the clinical spectrum and frequency of non-motor symptoms during off periods (NMOS) in Parkinson's disease (PD) patients with motor fluctuation. We compared clinical characteristics between PD patients with motor symptoms only (M-off) and those with both motor and non-motor symptoms (NM-off) during off periods. The association of NMOS with parkinsonian clin...

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Non-motor symptoms in Parkinson’s disease

Parkinson's disease (PD) includes motorial and non-motorial features, both negatively influencing patients’ life quality. While motor symptoms are well recognized and described, non motor symptoms are becoming a more recent focus of interest and research. This review aims to give an updated information about non-motor symptoms in PD. It comprehends three sections: 1) cognitive dysfunctions, 2) ...

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[Non-motor symptoms of Parkinson's disease].

Parkinson's disease has traditionally been viewed as a disease with only motor features. Nowadays, a wide variety of non-motor symptoms and signs are also recognised as being characteristic of the disease. Non-motor symptoms, most importantly autonomic dysfunction, neuropsychiatric symptoms and sleep problems, are prevalent in virtually all Parkinson's disease patients and influence the quality...

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Prodromal non-motor symptoms of Parkinson’s disease

The motor symptoms of Parkinson's disease (PD), bradykinesia, muscular rigidity, and tremor depend upon degeneration of the dopaminergic neurons in the substantia nigra pars compacta. Recent neuropathological studies show that the Lewy bodies, the intraneuronal landmark of PD, accumulate in several neuronal cell types in the brain. An ascending gradient of pathological involvement, from the med...

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Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease

BACKGROUND The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS We conducted a prospective sur...

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ژورنال

عنوان ژورنال: Journal of Korean Medical Science

سال: 2009

ISSN: 1011-8934

DOI: 10.3346/jkms.2009.24.2.311